San Francisco 49ers 27-7 Los Angeles Rams: result and reaction
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San Francisco 49ers meet Los Angeles Rams in the NFL. It is a Week 1 fixture. Kickoff is Thursday 10 September 2026 at 8:35 pm.
San Francisco 49ers and Los Angeles Rams both play in the American Football Conference – West.
The score on this page updates by itself once the game starts, so there is no need to reload. When the final whistle goes the result stays here, along with San Francisco 49ers and Los Angeles Rams coverage from the newsrooms we follow.
Starters to know
San Francisco 49ers start Brock Purdy (QB), Christian McCaffrey (RB), Mike Evans (WR), George Kittle (TE). Los Angeles Rams start Matthew Stafford (QB), Kyren Williams (RB), Puka Nacua (WR), Colby Parkinson (TE).
Injury watch
San Francisco 49ers: Nick Zakelj (IR. Injured Reserve), Brett Toth (IR. Injured Reserve), Austen Pleasants (IR. Injured Reserve. Expected Return Week 5), Mykel Williams (Physically Unable To Perform. Expected Return Week 5).
Los Angeles Rams: Keagen Trost (IR. Injured Reserve. Expected Return Week 5), Justin Dedich (IR. Injured Reserve. Expected Return Week 5), Alex Johnson (Questionable For Week 1 Vs. San Francisco), Matthew Caldwell (IR. Injured Reserve).
San Francisco 49ers have won 0 of their last 5 games this site has covered. Los Angeles Rams have won 1 of their last 3 games this site has covered.
Bookmark this page to follow San Francisco 49ers against Los Angeles Rams, or check the full NFL schedule.
Common questions
What time is the San Francisco 49ers vs Los Angeles Rams game?
Kickoff is 8:35 PM ET, 7:35 PM CT, 6:35 PM MT, 5:35 PM PT.
Is San Francisco 49ers vs Los Angeles Rams a division game?
San Francisco 49ers and Los Angeles Rams both play in the American Football Conference – West.
Where can I follow the live score for San Francisco 49ers vs Los Angeles Rams?
This page updates automatically once the game begins, and shows the final result once it ends.
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