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Home  /  Games

San Francisco 49ers vs Arizona Cardinals: preview, kickoff time and how to follow

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San Francisco 49ersvsArizona Cardinals

San Francisco 49ers meet Arizona Cardinals in the NFL. It is a Week 18 fixture. Kickoff is Sunday 10 January 2027 at 10:00 pm.

San Francisco 49ers represent the American Football Conference – West; Arizona Cardinals play in the National Football Conference – West.

The score on this page updates by itself once the game starts, so there is no need to reload. When the final whistle goes the result stays here, along with San Francisco 49ers and Arizona Cardinals coverage from the newsrooms we follow.

Starters to know

San Francisco 49ers start Brock Purdy (QB), Christian McCaffrey (RB), Mike Evans (WR), George Kittle (TE). Arizona Cardinals start Jacoby Brissett (QB), Jeremiyah Love (RB), Marvin Harrison Jr. (WR), Trey McBride (TE).

Injury watch

San Francisco 49ers: Nick Zakelj (IR. Injured Reserve), Brett Toth (IR. Injured Reserve), Austen Pleasants (IR. Injured Reserve. Expected Return Week 5), Mykel Williams (Physically Unable To Perform. Expected Return Week 5).

Arizona Cardinals: Will Johnson (Questionable For Week 1 At L.A. Chargers), Dadrion Taylor-demerson (Questionable For Week 1 At L.A. Chargers), Blake Gillikin (Questionable For Week 1 At L.A. Chargers), Josh Minkins (Questionable For Week 1 At L.A. Chargers).

Head-to-head history

In games this site has covered between these two sides, San Francisco 49ers have won 1 and Arizona Cardinals have won 0.

  • 24 August 2026 — Arizona Cardinals 38-42 Green Bay Packers
  • 24 August 2026 — Arizona Cardinals 0-0 Las Vegas Raiders
  • 24 August 2026 — Dallas Cowboys 0-0 Arizona Cardinals

The biggest margin in the series was 4 points, in Arizona Cardinals 38-42 Green Bay Packers on 24 August 2026. These two have combined for an average of 26.7 points per game across the meetings this site has on record.

San Francisco 49ers have won 0 of their last 5 games this site has covered. Arizona Cardinals have won 0 of their last 3 games this site has covered.

Bookmark this page to follow San Francisco 49ers against Arizona Cardinals, or check the full NFL schedule.

Common questions

What time is the San Francisco 49ers vs Arizona Cardinals game?
Kickoff is 9:00 PM ET, 8:00 PM CT, 7:00 PM MT, 6:00 PM PT.

Is San Francisco 49ers vs Arizona Cardinals a division game?
San Francisco 49ers represent the American Football Conference – West; Arizona Cardinals play in the National Football Conference – West.

Have San Francisco 49ers and Arizona Cardinals played before?
In games this site has covered between these two sides, San Francisco 49ers have won 1 and Arizona Cardinals have won 0.

Where can I follow the live score for San Francisco 49ers vs Arizona Cardinals?
This page updates automatically once the game begins, and shows the final result once it ends.